~ 070608 Vitamin D, a Natural ACE Inhibitor for High Blood Pressure
Jonathan Wright, MD reports in his January 2004 newsletter (Vol. 11 Issue 1) that research indicates that Vitamin D may act as a natural regulator of blood pressure by inhibiting the synthesis of Angiotensin II, a hormone that is a major cause of hypertension.
Production of Angiotensin II is dependent on Angiotensin Converting Enzyme (ACE). In individuals with hypertension Angiotensin II causes vasoconstriction as well as thickening of the heart muscle and artery walls. ACE inhibitors are a major class of blood pressure reducing drugs and can have a number of side effects including cough, headache, vertigo, skin rash, kidney disease and tissue swelling in the face and throat.
Epidemiological studies have shown that people who live in sunny, equatorial regions tend to have less hypertension. It is also known that people tend toward higher blood pressure during the winter months when their sun exposure is limited. Additionally, studies have found that subjects exposed to ultraviolet light, increasing vitamin D production, reported lowered blood pressure. Other small studies have found that vitamin D supplementation lowers both systolic and diastolic blood pressure.
Researchers have identified the mechanism by which vitamin D helps reduce blood pressure. Renin, a proteolytic enzyme, is produced when renal or vascular pressure is lowered (ischemia), splits a substance called angiotensinogen, producing angiotensin I, which is in turn changed to angiotensin II by ACE. Vitamin D inhibits this whole process by reducing the initial production of renin, resulting in lower blood pressure.
The current RDI for vitamin D is 200 IU. A 1999 study published in the Journal of Clinical Nutrition suggests that 10,000 IU is a safe daily maximum vitamin D dosage. Vitamin D toxicity studies have found that toxicity occurs in the range of 40,000 IU daily.
1-888-771-3905 | Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.
While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Extension Institute assumes no liability for inaccuracies or misstatements about products.