Source: Life Extension
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Excess levels of the enzyme 5-lipoxygenase or 5-LOX sets in motion inflammatory responses that has been linked to common degenerative effects in aging individuals.1-5 Normal aging results in higher-than-desired levels of 5-LOX.
The typical American diet adds to the danger. Foods rich in omega-6 fatty acids like red meat, poultry, eggs and dairy products, along with high-glycemic carbohydrates, trigger overproduction of arachidonic acid. In response to high levels of arachidonic acid, the body produces the 5-LOX enzyme.
5-LOX breaks down arachidonic acid to pro-inflammatory compounds like leukotriene B4,6 a molecule that attacks joints, arterial walls, and other tissues. 5-LOX itself facilitates undesirable cell division changes.
The good news is that extract of the Indian plant Boswellia serrata has been shown to neutralize 5-LOX. Used for centuries to help with inflammatory issues, boswellia acts a natural 5-LOX inhibitor, intervening at the cellular level to block its unwanted effects. Confirmatory data reveal that a compound contained in boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)7,8 is the key to its beneficial action. The problem is that boswellia is not readily absorbed into the blood.9
For this reason, a patent-pending, standardized form of boswellia called AprèsFlex™ is being introduced that absorbs into the blood 52% more than previously available boswellia extracts.9 Each 100 mg vegetarian capsule of 5-LOX Inhibitor with AprèsFlex™ is standardized to provide 20% of active AKBA from boswellia. Most people need only one capsule a day.Supplement FactsServing Size:
vegetarian capsuleServings Per Container:
60Amount Per Serving
- AprèsFlex™ (Boswellia serrata) extract (gum resin) [std. to 20% 3-O-acetyl-11-keto-ß-boswellic acid (AKBA) (20 mg)] - 100mg
microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.
AprèsFlex™ is a trademark of Laila Nutraceuticals exclusively licensed to PL Thomas--Laila Nutra LLC. International patents pending.Dosage and Use:
To inhibit the 5-lipoxygenase enzyme, take one capsule daily with or without food, or as recommended by a healthcare practitioner.Note:
Not available for sale to Food and Drug Stores.References
- Neurobiol Aging. 2007 Sep;28(9):1457-62.
- Cardiovasc Psychiatry Neurol. 2009;2009:174657.
- Free Radic Biol Med. 2009 Jul 1;47(1):62-71.
- Rejuvenation Res. 2009 Feb;12(1):15-24.
- Available at: http://www.cdc.gov/nchs/fastats/lcod.htm. Accessed July 29, 2011.
- Curr Opin Investig Drugs. 2009 Nov;10(11):1163-72.
- Wien Med Wochenschr. 2002;152(15-16):373-8.
- J Ethnopharmacol. 2006 Sep 19;107(2):249-53.
- Mol Cell Biochem. 2011 Aug;354(1-2):189-97.
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