AMPK is an enzyme that serves as the body's master regulating switch. It inhibits multiple degenerative factors by revitalizing aging cells.1
Found in every cell,2,3 AMPK promotes longevity factors that have been shown to extend life span in numerous organisms.1,4 Increasing AMPK signaling "turns off" many destructive effects of aging, thus enabling cells to return to their youthful vitality.5
Life Extension® scientists have compiled years of research to create AMPK Activator, a specialized dual-extract formulation that supports AMPK activation for health optimization. This natural formula supports AMPK enzymatic activities required to safely support a more youthful cellular environment.
Importance of AMPK
Greater AMPK (adenosine monophosphate-activated protein kinase) activation has been shown to help target damaging factors of aging.5 Studies show increased AMPK activity supports reduced fat storage,6 new mitochondria production,7 and the promotion of healthy blood glucose and lipids already within normal range.4
An extract of the plant Gynostemma pentaphyllum was traditionally used in Asian medicine to promote longevity and scientists now know why—G. pentaphyllum promotes AMPK activation.8-10 In one of many studies showing a wide variety of benefits, researchers documented a 1-inch reduction in abdominal circumference in overweight individuals who took 450 mg daily of G. pentaphyllum extract for 12 weeks.11
Trans-tiliroside, extracted from plants such as rose hips, also boosts AMPK activation, but triggers different downstream metabolic benefits than G. pentaphyllum.12-14 Among its many benefits, a low equivalent dose of 56 mg daily trans-tilirosidehas been shown by researchers in preclinical studies to promote healthy blood glucose levels and body weight already within normal range.15
Anti-Aging Discovery that Cannot be Overlooked
Scientists uncovered the cell-energizing effect of AMPK in the 1970s. Since then, an exponential volume of data (over 7,500 published studies) documents the critical role that activated AMPK plays in maintaining life-sustaining cellular functions.
Those seeking to meaningfully extend their healthy life span should ensure they optimally activate their cellular AMPK. The reason this is so important is that in response to aging, excess calorie consumption, and/or low levels of physical activity, AMPK activity markedly declines.
A targeted way of reversing cellular depletion of this critical enzyme is to take the new AMPK Activator formula that comprises a dual-extract, plant-based formulation.
Gynostemma pentaphyllum extract (leaf)
Rose hip extract [from dog rose
(Rosa canina) (stem and leaf)
std. to 5% trans-tiliroside (18.6 mg)]
vegetable cellulose (capsule), microcrystalline cellulose, tapioca starch, dextrin, ascorbyl palmitate, silica.
Take two (2) capsules (servings) with the first meal of the day and one (1) capsule (serving) with the second meal, or as recommended by a healthcare practitioner.
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10. Biotechnol Lett. 2012 Sep;34(9):1607-16.
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15. Bioorg Med Chem Lett. 2007;17(11):3059-64.