Life Extension Foundation
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One of the most deleterious effects of "normal" aging is rising glucose (blood sugar) levels. Excess glucose floods cells throughout the body, overwhelming their metabolic machinery and increasing the mitochondrial production of free radicals. Failure to control this excess sugar can lead to numerous health issues.
Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), supports healthy blood sugar metabolism and acts through several mechanisms to block the biochemical pathways by which high blood sugar wreaks havoc throughout the body.1 For example, the enzyme transketolase is critical to blood sugar metabolism. Like many enzymes, transketolase requires a cofactor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water soluble, which makes it less available to the interior of the cell. Since benfotiamine is fat soluble, it enters areas of the body where water-soluble thiamine cannot penetrate.
In a landmark study, benfotiamine increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage.1 Benfotiamine also blocks the activation of the transcription factor known as nuclear factor-kappa beta (NF-kB), which is implicated in numerous inflammatory conditions.1
Benfotiamine with thiamine is a low-cost dietary supplement that can help maintain already-normal blood sugar levels and support the health of the nerves, kidneys, eyes, blood vessels, and heart.References
1. Nature Med. 2003 Mar;9(3):294-9.Supplement FactsServing Size:
1 capsuleServings Per Container:
120Amount Per Serving
- Vitamin B1 (as thiamin HCl) - 25mg
- Benfotiamine - 100mg
microcrystalline cellulose, vegetable capsule, silica, magnesium stearate.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.Dosage and Use
Take one capsule four times daily with or without food, or as recommended by a healthcare practitioner.
If using Mitochondrial Energy Optimizer or Super Carnosine, only two to three capsules daily are needed to reach the optimal dose of 400 mg daily.
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