ENHANCED NATURAL SLEEP WITHOUT MELATONIN

Source: Life Extension Foundation

Ingredients: See below

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If you find you don't sleep well with melatonin—or are already taking one of Life Extension®'s stand-alone melatonin formulas at a different dose that works for you—Life Extension offers Enhanced Natural Sleep® without Melatonin.

The consequences of sleep deprivation go far beyond the miseries of fatigue and diminished performance. Decades of clinical research document that a good night's rest supports nearly all systems of the body, including:

• Skin health and youthful appearance^1-4
• Healthy collagen formation^5-8
• Insulin levels already within normal range^9-11
• Healthy body weight^12,13
• Glucose levels already within normal range^14,15
• Blood pressure already within normal range^16,17
• Healthy cell division^18-20
• Cardiovascular health^21-24
• Good mood^25-27

Scientists attribute sleep-related difficulties to the unprecedented levels of stress most of us endure in today's fast-paced world.

To add insult to injury, sleep quality and duration decline as we grow older--at a time when we need the health benefits of a good night's rest more than ever.

To combat the profound impact of chronic sleep debt on health and youthful appearance, Life Extension® now offers Enhanced Natural Sleep® with Dual-Action Melatonin. This new formula brings together three clinically validated, natural compounds that have been shown to support healthy, restful sleep, promote healthy response to stress, while targeting sleep debt-related factors associated with skin aging. The three ingredients are:

1. Bioactive Milk Peptides (Lactium®) is a cutting-edge nutrient complex consisting of patented bioactive peptides found naturally in milk. Used widely in Europe to promote sustained and restful sleep patterns, published studies reveal that these bioactive milk peptides also promote relaxation, help with stress and support daytime cognition.
   
   A group of 60 women reporting a variety of sleep-related difficulties experienced as much as 65.6% improvement in their symptoms with 150 milligrams per day of these bioactive milk peptides.28 In another study, the same 150 milligram dose induced substantial improvements across 27 markers of sleep quality and stress response in 165 healthy adults.29 And in a third study, a group of healthy men and women taking 150 milligrams per day of these bioactive milk peptides for one month experienced a 50% improvement in sleep quality after two weeks and needed 30% less time to fall asleep after 4 weeks.30
   
   
2. Melatonin (very low dose). Melatonin levels naturally decline with age and adversely affect sleep patterns in many people. Both immediate and timed-release melatonin has been shown to support restful sleep. So much so that time-release melatonin has been licensed since June 2007 in Europe and other countries for the short-term treatment of sleep disorders.31
   
   
3. Sendara™. A proprietary nutrient complex consisting of ashwagandha and Indian gooseberry extracts. Prized in traditional cultures for their ability to promote healthy skin function and appearance, these plant-based compounds have since gained substantial clinical validation. Indian gooseberry provides broad-spectrum antioxidant support and has been used to preserve youthful skin health and appearance in many skin care products.32-35 Ashwagandha promotes a healthy response to stress, yielding 62% reductions in anxiety compared to placebo with just 125 milligrams per day in one clinical study.36

Enhanced Natural Sleep® with Dual-Action Melatonin should be taken 30-60 minutes before bedtime to help with sleep.

Supplement Facts

Serving Size: 1 capsule

Servings Per Container: 30

Amount Per Serving

• Sendara™ [proprietary blend of Ashwagandha (Withania somnifera) extract (root and leaf) standardized to withanolide glycoside conjugates and Amla (Phyllanthus emblica) extract (fruit) standardized to low molecular weight hydrolysable tannins] - 200mg
• Casein decapeptide† (Bioactive Milk Peptides) - 150mg

Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate, vegetable oil.

Contains milk (casein decapeptide).

Patent pending Sendara™ is a trademark of Nutragenesis, LLC.

† Lactium® is used under license.

Dosage and Use: Take one capsule daily 30 to 60 minutes before bedtime, with or without food, or as recommended by a healthcare practitioner.

Caution: Consult your healthcare provider before taking this product if you are being treated for a medical condition (especially autoimmune or depressive disorders). Use caution if combining with alcohol. This product is not intended for children, pregnant or lactating women, or women trying to become pregnant. Do not attempt to drive or operate heavy machinery after taking this product.

References

1. J Invest Dermatol. 2001 Aug;117(2):309-17.
2. Arerugi. 2010 Jun;59(6):706-15.
3. Dermatitis. 2007 Jun;18(2):82-91.
4. J Invest Dermatol. 2005 Mar;124(3):587-95.
5. The Physiology and Pathophysiology of the Skin. London: Academic Press; 1980:2147-55.
6. Sleep Med Rev. 2005 Oct;9(5):355-64.
7. Curr Opin Pulm Med. 2005 Nov;11(6):481-4.
8. Nat Rev Neurosci. 2009;10(3):199-210.
9. Obes Rev. 2009 Nov;10 Suppl 2:37-45.
10. BMC Public Health. 2007 Jun 28;7:129.
11. Science. 2010 Dec 3;330(6009):1349-54.
12. J Clin Sleep Med. 2007 Dec 15;3(7):681-8.
13. Obesity (Silver Spring). 2009 Apr;17(4):767-71.
14. Int J Obes (Lond). 2009 Jan;33(1):46-53.
15. Am J Physiol. 1996 Aug;271(2 Pt 1):E261-70.
16. Am J Hypertens. 2010 Dec;23(12):1286-91.
17. Lakartidningen. 2002 Jan 17;99(3):154-7.
18. Occup Med (Lond). 2010 Jan;60(1):10-20.
19. Chronobiol Int. 2011 Feb;28(1):76-80.
20. Lipids Health Dis. 2010 Oct 30;9:125.
21. Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):294-302.
22. Prog Cardiovasc Nurs. 2004 Spring;19(2):56-9.
23. Sleep. 2010 Aug 1;33(8):1037-42.
24. Sleep. 2009 Mar 1;32(3):295-301.
25. J Sleep Res. 1997 Sep;6(3):179-88.
26. Psychiatry Clin Neurosci. 2003 Jun;57(3):265-70.
27. Principles and Practice of Sleep Medicine. 3rd ed. Philadelphia, PA: WB Saunders; 2000:1140-57.
28. Eur J Clin Nutr. 2007 Apr;61(4):536-41.
29. So Ken Study: Effect of Lactium® on sleep disorders. October, 2006.
30. Open Sleep J. 2009;2:26-32
31. BMC Med. 2010 Aug 16;8:51.
32. Skin Pharmacol Appl Skin Physiol. 2002;15(5):374-80.
33. J Surg Res. 2008;144(1):94-101.
34. J Ethnopharmacol. 2010 Oct 28;132(1):109-14.
35. J Cosmet Sci. 2009;60(4):395-403.
36. JANA. 2008;11(1):50-6.

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