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Read More . . . Gamma E Tocopherol - The primary purpose of supplementing with vitamin E is to suppress damaging free radicals. Scientific studies have identified the gamma-tocopherol form of vitamin E as being critical to human health. New research shows that sesame lignans increase gamma-tocopherol levels in the body while reducing free radical damage. In response to these findings, Life Extension has reformulated the popular Gamma E Tocopherol supplement to replace tocotrienols with sesame lignans. On August 11, 2004, JAMA published an extensive review article extolling the benefits of gamma-tocopherol. In its article, JAMA discusses the inconsistent findings about alpha-tocopherol and presents compelling evidence that gamma-tocopherol is the form of vitamin E most likely to reduce the risk of degenerative disease. The JAMA article reviewed the scientific basis for vitamin E's cardioprotective effects. It then went on to describe why studies that showed no efficacy to vitamin E supplementation might have been flawed. The reasons cited for why these studies failed to provide reliable results include selection of subjects, stage of disease, end points, dosage, and source of the vitamin E. Another issue raised in the JAMA review is that vitamin E's mechanism of preventing heart disease is most likely related to its ability to suppress LDL oxidation. A more targeted approach, JAMA asserts, would be to include only patients with enhanced levels of oxidative stress and low plasma levels of vitamin E in order to determine those most likely to benefit from antioxidant treatment. A wide range of toxic factors�including excess blood levels of homocysteine, C-reactive protein, fibrinogen, insulin, glucose, and triglycerides�causes atherosclerotic heart disease. It is impractical to expect vitamin E by itself to prevent atherosclerosis. If healthy arteries are to be maintained, other pathological mechanisms have to be addressed as well. Gamma-Tocopherol's Cancer-Preventive Effects The JAMA article notes that most clinical trials designed to examine vitamin E's ability to prevent disease have used alpha-tocopherol. The article then considers recent molecular and epidemiological studies that have prompted researchers to examine the potential benefits of the gamma-tocopherol form of vitamin E. One study cited by JAMA showed that increased levels of gamma-tocopherol were associated with a significantly reduced risk of prostate cancer. The JAMA article goes on to note that the anticancer effects of high concentrations of selenium and alpha tocopherol were observed when gamma-tocopherol concentrations were also high. Another group of researchers interviewed by JAMA are investigating whether gamma-tocopherol can inhibit the growth of colon cancer. These researchers hypothesize that vitamin E levels inside cells are more important than blood levels in protecting DNA against the molecular mechanisms that can lead to cancer. Part of this rationale is that colon cancer cells take up gamma tocopherol much more effectively than alpha tocopherol. Furthermore, according to the JAMA article, when alpha and gamma-tocopherol are taken up together into cells, the presence of gamma-tocopherol increases the level of alpha-tocopherol. The researchers interviewed by JAMA point out that gamma-tocopherol has unique properties that alpha-tocopherol does not have, including the ability to neutralize certain free radicals and suppress expression of a gene (ras-p21) that is known to cause cancer. The JAMA article reports on a rat study that showed gamma-tocopherol provides antioxidant protection to the cells lining the colon and to fecal material (possibly decreasing the production of mutagens). Another study cited by JAMA examined the influence of gamma-tocopherol on the expression of another gene called peroxisome proliferator activated receptor y (PPARy). This gene (PPARy) is a promising target for the prevention and treatment of colon and other cancers. Activation of PPARy with certain drugs such as Rezulin�, the JAMA article points out, can reduce tumor growth by inhibiting cellular proliferation and inducing programmed cell death (apoptosis). In January 2004, the journal Free Radical Biology and Medicine reported on "new and unexpected biological activities" with regard to gamma-tocopherol. The scientists stated that "these other tocopherols" possess anti-inflammatory, anticancer, and natriuretic functions. Epidemiological data were cited suggesting that gamma-tocopherol helps prevent certain types of cancer and heart attack better than alpha-tocopherol. The scientists concluded by warning that the: ". . . potential public health implications are immense, given the extreme popularity of alpha-tocopherol supplementation which can unintentionally deplete the body of gamma-tocopherol." This new formula provides more gamma-tocopherol than the previous version, and is fortified with standardized sesame lignans to augment the antioxidant effects of gamma-tocopherol. Learn more about Vitamin E . . . Supplement Facts Serving Size: 1 softgel Servings Per Container: 60 Amount Per Serving
Dosage and Use: Take 1 softgel per day. For optimal absorption, take with food. Caution: Because Vitamin E inhibits blood clotting, use with caution if you are taking anticoagulant drugs or have a bleeding disorder. This product should not be used by individuals who have an allergy to sesame. How to Order To order online, click on the "Order" box below. To see a list of all supplements, please check our Index or use our Search feature. If you have any questions, please contact us at info@lifeextensionvitamins.com, 1-510-527-3005 or 1-888-771-3905. |
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| ~ Gamma Tocopherol Under Attack - Not the Whole Story |
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