Life Extension Foundation
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The phytonutrient profile of Ginkgo Biloba Certified Extract is comparable to the Gbe 24/6 extract used in clinical studies worldwide and monographed in German Commission E. The health regulatory agency that regulates ginkgo purity in Germany mandates that ginkgo not contain more than 5 ppm of ginkgolic acid. Life Extension's new low cost ginkgo contains less than 1 ppm of this toxic part of the ginkgo leaf. Ginkgolic acid is a substance related to anacardic acid (poison ivy) and may cause an allergic reaction in some people. Ginkgo Biloba Certified Extract has the lowest ginkgolic acid of any product on the market.
A presentation on October 31, 2005 at the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research
meeting in Baltimore revealed that consuming ginkgo biloba is associated with a 60 percent lower risk of developing ovarian cancer than that experienced by women who did not take the herb.
Massachusetts researchers, led by Drs. Bin Ye and Daniel Cramer of Brigham and Women's Hospital in Boston, examined data from 600 women with ovarian cancer and 640 healthy matched controls. Ten percent of the women with cancer reported the use of herbal supplements at least once per week for six months or longer prior to their diagnosis, which was comparable to the number of healthy women who reported herbal supplement use.
Of the most commonly used herbs, only ginkgo was found to be associated with a decreased risk of ovarian cancer. Over 4 percent of the healthy women compared to 1.6 percent of those with ovarian cancer reported using ginkgo. Among women who had nonmucinous ovarian cancers, ginkgo use was associated with a 65-70 percent risk reduction.
In vitro investigation found that specific compounds in ginkgo stopped the growth of ovarian cancer cells. Dr Ye explained: "Among the mixture of ginkgo chemicals we found laboratory evidence that ginkgolide A and B--terpene compounds--are the most active components contributing to this protective effect . . . While the detailed mechanism of ginkgo action on ovarian cancer cells is not yet well understood, from the existing literature it most likely that ginkgo and ginkgolides are involved in anti-inflammation and antiangiogenesis processes via many extra- and intra-cellular signal pathways. In the future, these findings could potentially offer a new strategy for ovarian cancer prevention and therapy, using the active forms of ginkgolides."
Ginkgo Biloba Certified Extract has high levels of ginkgolide B (>0.8%), which is the most studied terpene lactone, and thought to be a potent inhibitor of platelet activating factor (PAF). PAF is a powerful inflammatory mediator.
There are 120mg of this standardized ginkgo extract in each capsule of Life Extension Super Booster. If you take the Super Booster product, you do not need to take any additional ginkgo.
Ginkgo biloba extract is a potent antioxidant and scavenger of most free radical species, such as hydroxyl and peroxyl radicals and superoxide anions.1
It is known to protect the energy-producing mitochondria within the cells, thus enhancing oxygen utilization and cellular respiration.
In a study to determine whether ginkgo extract could prevent age-associated cellular changes, the brain and liver mitochondria of old mice fed ginkgo extract in their drinking water was compared to those of young and old control mice. Mitochondria from the rats given ginkgo exhibited significantly less genetic damage, peroxide generation and oxidation of the crucial antioxidant glutathione than the nonsupplemented rats. In addition, mitochondria from the old rats given the ginkgo extract resembled those of the young rats much more closely, being similar in size and morphology. The study concluded that standardized ginkgo extract prevents age-related decline in mitochondrial structure and function by protecting mitochondria from oxidative damage.2
Supplement FactsServing Size:
- Du G, Willet K, Mouithys-Mikalad A, Sluse-Goffart CM, Droy-Lefaix MT, Sluse FE, EGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation. Free Radic Biol Med 1999; Sep;27(5-6):596-604.
- Sastre J, Pallarado FV, Garcia de la Asuncion J, Vina J. Mitochondria, oxidative stress and aging. Free Radi Res 2000;Mar;32(3):189-98.
1 capsuleServings Per Container:
365Amount Per Serving:
Ginkgo biloba (leaf) extract [standardized for 24% ginkgoflavon-glycosides (28.8 mg) 6% terpene lactones (7.2 mg) and <1 ppm ginkgolic acid] - 120mgOther ingredients:
rice flour, gelatin, magnesium stearate.Dosage and Use:
Take one capsule per day, or as directed by a healthcare practitioner. This product is best utilized when taken with food.Caution:
If you are taking anticoagulants or MAO inhibitors, consult your doctor before taking ginkgo. Not for use by pregnant or lactating women. The pharmaceutical grade botanical extract in Ginkgo Biloba Certified Extract has been concentrated and dual standardized to ensure the highest quality, consistency, and biological activity. Ginkgo Biloba Certified Extract contains the lowest level of ginkgolic acid available, even lower than the stringent 5 ppm German Commission E limit. Ginkgolic acid is an allergen for some people and is present in much higher levels in lower quality products.
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