Source: Life Extension Foundation Ingredients: See below. Sale Price: $13.25 Take advantage of FREE air shipping in the USA! Read More . . . HCA (hydroxycitric acid) is a close relative of citric acid, the agent that gives citrus fruits their characteristic tart flavor. HCA is obtained as a 50% standardized extract of Garcinia cambogia, a small fruit from southern India, where it has been used for centuries as a food preservative, flavoring agent, and digestive aid. HCA exerts its weight control effect through its inhibition of the enzyme ATP citrate lyase, playing a critical role in energy storage.1 When calorie intake exceeds the body's energy needs, the excess glucose is converted into glycogen, which is stored in the liver and muscles for future conversion into energy. Weight gain occurs after the body's capacity for glycogen storage is reached. At this point, glucose from excessive calorie intake is converted into acetyl coenzyme A via a metabolic pathway involving ATP-citrate lyase and then into fat molecules, which are stored in fat cells. HCA has been shown to bind to ATP-citrate lyase to reduce the production of acetyl coenzyme A and also increase the ability of the liver and muscles to synthesize and store glycogen.2 Research has shown that HCA is absorbed with blood levels of HCA peaking two hours after ingestion and remaining in the blood for between four and nine hours after ingestion.3,4 Szutowicz A, Stepien M, Lysiak W, Angielski S. Effect of (-)hydroxycitrate on the activities of ATP citrate lyase and the enzymes of acetyl-CoA metabolism in rat brain. Acta Biochim Pol. 1976;23(2-3):227-34. Lim K, Ryu S, Nho HS, Choi SK, Kwon T, Suh H, So J, Tomita K, Okuhara Y, Shigematsu N. (-)-Hydroxycitric acid ingestion increases fat utilization during exercise in untrained women. J Nutr Sci Vitaminol (Tokyo). 2003 Jun;49(3):163-7. Loe YC et al. "Gas chromatography/mass spectrometry method to quantify blood hydroxycitrate concentration." Anal Biochem 292(1):148-54, 2001. Loe YC et al. "Time course of hydroxycitrate clearance in fasting and fed humans." FASEB J 15(4):632, Abs. 501.1, 2001. Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK, Satyanarayana S. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab. 2004 May;6(3):171-80. Supplement Facts Serving Size: 1 capsule Servings Per Container: 90 Amount Per Serving Garcinia cambogia fruit powder extract (50%) - 500mg Supplying hydroxycitric acid (HCA) - 250mg Other ingredients: gelatin and water. Dosage and Use Take one capsule three times daily with one capsule CitriChrome, 45 minutes before meals. HCA may be even more effective when taken with chromium. How to Order To order online, click on the "Order" box below. To see a list of all supplements, please check our Index or use our Search feature. If you have any questions, please contact us at info@lifeextensionvitamins.com, 1-510-527-3005 or 1-888-771-3905. hcaRetail Price: $16.20Sale Price: $13.25 90: caps/250mg.ea CITRICHROME - Natural Weight Loss citrichromeRetail Price: $22.95Sale Price: $16.95 90: caps ~ Garcinia Cambogia Offers Weight Loss without the "Pangs" of Low Blood Sugar FREE AIR MAIL SHIPPING IN THE U.S.! The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Copyright 1997-2008 Life Extension Vitamin Supplies and Life Extension Institute, Inc. All rights reserved.