~ How Coq10 Protects Brain Cells
Mitochondrial dysfunction is at the basis of many neurodegenerative diseases. The mitochondria are the "powerhouses" of cells, providing energy that fuel critical cellular functions. Aging and cumulative oxidative stress, however, impede the functioning of the mitochondria over time, resulting in dysfunction and demise.
Neuro-degenerative diseases involve early and accelerated nerve cell destruction. One of the primary causes of neuronal death is excitotoxicity, whereby the brain becomes over-sensitized to the neurotransmitter glutamate, whose role it is to send excitatory impulses.
Some scientists theorize that excitotoxicity can also result from a diminished energy level among neurons, which may lower their defenses against various neurotoxins and thus precipitate malfunctioning and death. Researchers now suggest that this bioenergy decline may be intimately involved with the progression of Parkinson's disease. Coenzyme Q10 seems to offer protection for neurons against the excitotoxicity of exposure to L-glutamate.*
The region of the brain affected by Parkinson's disease is also afflicted by excessive oxidative stress, more than is evident elsewhere in the brain. This oxidative stress is especially damaging to neurons whose energy levels are already taxed by neurotoxicity and excitotoxicity. According to a study published in a year 2001 issue of Neurotoxicology,* both neurotoxins and excitotoxins are "thought to involve free radical production, compromised mitochondrial activity and excessive lipid peroxidation." Logic would suggest then that restoring neuronal energy levels might boost these defenses and research has demonstrated that to be the case.
*Mazzio E et al. Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cells. Neurotoxicology 2001 Apr;22(2):283-8.
To see a list of all supplements, please check our Index or use our Search feature.
If you have any questions, please contact us at email@example.com, 1-510-527-3005 or 1-888-771-3905.
FREE Shipping in the CONTINENTAL UNITED STATES - ALL ORDERS
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.
While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Extension Institute assumes no liability for inaccuracies or misstatements about products.