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Read More . . . The loss of cellular vitality is caused by a number of factors, including mitochondrial problems, glycation, and free-radical reactions. Life Extension® members have access to a state-of-the-art nutritional formula called Mitochondrial Energy Optimizer that protects delicate cellular structures and enables cells to perform life-sustaining metabolic processes. In this new formula, we have replaced rhodiola, SOD, thiamine, and carnitine with peridoximine (B6), luteolin, the newset form of r-lipoic acid, and some sodium to increase the bio-availability of the r-lipoic acid. Glycation and Aging As humans age, their proteins become irreversibly damaged by lethal glycation reactions. Glycation is the cross-linking of proteins and sugar to form nonfunctioning structures in the body, which can lead to alterations of normal cell function. Carnosine is not only the premier antiglycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.1-5 The new Mitochondrial Energy Optimizer is designed to counteract age-related structural and functional changes by providing the following unique ingredients: Unremitting systemic inflammation is involved with virtually every undesirable consequence of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to suppress these dangerous inflammatory cytokines.6-11 Glucose and Free Radicals Benfotiamine blocks multiple destructive biochemical pathways, including advanced glycation end-products' (AGEs) formation pathway, which are induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 74–85 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal.12-14 Benfotiamine can correct endothelial cell defects induced by high glucose. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.15 Aging results in protein glycation and the formation of AGEs in tissues throughout our body. Pyridoxamine, a form of vitamin B6, is an efficient AGE inhibitor — or cross-link breaker -- that has been validated to protect the body's aging proteins against carbonyl stress via multiple independent mechanisms.16-17 Destructive free radical activity in the mitochondria plays a major role in the loss of cellular vitality. A new microencapsulated Bio-Enhanced™ R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.18-21 The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. Acetyl-L-carnitine arginate is a patented form of carnitine that also stimulates the growth of neurites in the brain. Supplement Facts Serving Size: 4 capsules Servings Per Container: 30 Amount Per Serving
Contains soybeans. This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives. Bio-Enhanced™ is a trademark and Na-RALA® is a registered trademark of Geronova Research, Inc. Pureolin™ is a trademark of Pharma Science Nutrients, Inc., and is used here under license. All rights reserved worldwide. Dosage and Use: Take two capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner. This product can be taken with or without food. References 1. Hormones (Athens). 2008 Apr-Jun;7(2):123-32. 2. Protein Pept Lett. 2008;15(4):385-91. 3. J Alzheimers Dis. 2007 May;11(2):229-40. 4. Ann N Y Acad Sci. 2006 May;1067:369-74. 5. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12. 6. Life Sci. 2007 Nov 30;81(23-24):1602-14. 7. J Nutr. 2006 Jun;136(6):1517-21. 8. Biochem Pharmacol. 2005 Jan 15;69(2):241-8. 9. Immunology. 2005 Jul;115(3):375-87. 10. Am J Respir Crit Care Med. 2002 Mar 15;165(6):818-23. 11. Eur J Pharmacol. 2006 Jul 10;541(1-2):95-105. 12. Nat Med. 2003 Mar;9(3):294-9. 13. Acta Diabetol. 2001;38(3):135-8. 14. Diabetes. 2006 Aug;55(8):2231-7. 15. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7 16. Ophthalmic Res. 2006;38(5):294-302. 17. Nephrol Dial Transplant. 2008 Feb;23(2):518-24. 18. Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9. 19. FASEB J. 1999 Feb;13(2):411-8. 20. Antioxid Redox Signal. 2000 Fall;2(3):473-83. 21. Biochem Mol Biol Int. 1995 Oct;37(2):361-70. How to Order To order online, click on the "Order" box below. To see a list of all supplements, please check our Index or use our Search feature. If you have any questions, please contact us at info@lifeextensionvitamins.com or 1-888-771-3905. |
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FREE AIR MAIL SHIPPING IN THE UNITED STATES!  The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Copyright 1997-2009 Life Extension Vitamin Supplies and Life Extension Institute, Inc. All rights reserved. |