Item# LEF01868
Retail Price: $94.00
Your Price: $70.50

Mitochondrial Energy Optimizer with BioPQQ®, 120 capsules, Item# 01868 (formerly Item# 01768)

Known as "cellular dynamos," healthy mitochondria produce the energy that powers cells.

Aging is characterized by inflammation, glycation and mitochondrial decay. Mitochondria are the energy-producing powerhouses of the cells and are found in highest concentrations in metabolically active organs such as the brain, heart, and skeletal muscles. Currently, the only known strategies to generate new mitochondria are long-term, strenuous aerobic exercise or caloric restriction, which are difficult or impractical for most people to implement.

Mitochondrial Energy Optimizer contains the following unique ingredients:

  • PQQ. This novel micronutrient represents a breakthrough in mitochondrial support. PQQ has been shown to actually trigger the creation of new mitochondria1 and protect the delicate structures of existing mitochondria.2-6
  • Carnosine. Carnosine has been shown to protect cellular structures against advanced glycation end-products (AGEs). These damaging compounds are formed when proteins or lipids are cross-linked with sugars in a process known as glycation. Glycation is linked to a host of negative age-related events in the neurologic, vascular, renal and ocular areas.7-17 Carnosine is a powerful anti-glycating agent, and protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.18-24
  • Luteolin. Luteolin is a plant-derived flavonoid that has been shown to inhibit inflammatory factors, which have been linked to virtually every undesirable consequence of aging. Luteolin works by suppressing pro-inflammatory cytokines, including interleukin-1 and tumor necrosis factor-alpha.25-34
  • Benfotiamine. Benfotiamine operates along multiple pathways to protect cellular integrity. It has been shown in studies to protect cells against the damaging effects of excess glucose by increasing glucose metabolism and protecting against the formation of AGEs.35-43 Studies have shown that the ideal fasting glucose levels are between 70–85 mg/dL. Many aging people, however, have fasting glucose levels above 90 mg/dL. Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels already within normal range. Additionally, benfotiamine has been shown to act as an antioxidant that supports healthy DNA function.44
  • Pyridoxal 5'-Phosphate. This active form of vitamin B6 has been shown to protect against glycation reactions caused by both lipids and proteins.45-49
  • R-lipoic acid. R-lipoic acid protects mitochondria against free radicals while promoting youthful mitochondrial function. The R-lipoic form is more potent than the other form of lipoic acid on the supplement market.50-57
  • Taurine. This amino acid supports neurite growth58 and powerfully protects the mitochondria59 from oxidative damage to enhance energy production within cells.58,60,61  Taurine is prevalent throughout the body62 and found in especially high amounts in the metabolically active cells that require high mitochondrial energy production (brain,62 nerve, eye cells,63 heart,64 and skeletal muscle65).

Supplement Facts

Serving Size: 4 capsules

Servings Per Container: 30

Amount Per Serving

  • Vitamin B6 (as pyridoxal 5'-phosphate) - 100mg
  • Sodium - 18mg
  • Carnosine - 1000mg
  • L-Taurine - 800mg
  • Benfotiamine - 150mg
  • R-Lipoic Acid (as microencapsulated Bio-Enhanced® stabilized Na-RALA sodium R-lipoate) - 150mg
  • BioPQQ® Pyrroloquinoline quinone disodium salt - 10mg
  • Luteolin [from orange extract (fruit)] - 8mg

Other ingredients: vvegetable cellulose (capsule), microcrystalline cellulose, candelilla wax, beeswax, stearic acid, silica, corn starch, acacia gum, calcium silicate.


BioPQQ® is a registered trademark of MGC (Japan).

Bio-Enhanced® is a registered trademark of Geronova Research, Inc.

Dosage and Use: Take two capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.

This product can be taken with or without food.


  1. J Biol Chem. 2010. Jan 1;285:142-52.
  2. Alt Med Rev. 2009; 14(3):268-77.
  3. Entrez Gene: PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [ Homo sapiens ] GeneID: 10891.
  4. Entrez Gene: CREBBP CREB binding protein [ Homo sapiens ] GeneID: 1387.
  5. Exp Gerontol. 2015 Jun;66:1-9.
  6. Eur Spine J. 2015 Aug;24(8):1702-10.
  7. Diabetologia. 2002 Oct;45(10):1457-62.
  8. Pathol Biol (Paris). 2003 Dec;51(10):543-9.
  9. Brain Res Rev. 2003 Mar;41(2-3):306-23.
  10. Arthritis Rheum. 2004 Apr;50(4):1207-15.
  11. Med Hypotheses. 2004;62(2):275-9.
  12. Can J Physiol Pharmacol. 2000 Oct;78(10):848-55.
  13. Ann N Y Acad Sci. 2001 Apr;928:48-53.
  14. Arthritis Rheum. 2002 Jan;46(1):114-23.
  15. J InvestDermatol. 2002 Aug;119(2):489-98.
  16. Kurume Med J.2002;49(1-2):7-13.
  17. Curr Pharm Des. 2008;14(10):946-52.
  18. J Alzheimers Dis. 2007 May;11(2):229-40.
  19. Curr Clin Pharmacol.2011 Nov;6(4):236-59.
  20. Ann N Y Acad Sci. 2006 May;1067:369-74.
  21. Eur J Pharmacol. 2011 Jan 10;650(1):184-94.
  22. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
  23. Neurobiol Aging. 2014 Jun;35(6):1469-72.
  24. Atherosclerosis. 2014 Feb;232(2):403-9.
  25. Life Sci. 2007 Nov 30;81(23-24):1602-14.
  26. J Nutr. 2006 Jun;136(6):1517-21.
  27. J Neuroinflammation. 2008 Sep 25;5:41.
  28. Immunology. 2005 Jul;115(3):375-87.
  29. Am J Respir Crit Care Med. 2002 Mar 15;165(6):818-23.
  30. Eur J Pharmacol. 2006 Jul 10;541(1-2):95-105.
  31. Neurosci Lett. 2008 Dec 26;448(2):175-9.
  32. Biochimie. 2011 Mar;93(3):506-12.
  33. J Pharmacol Exp Ther. 2011 Sep;338(3):1013-22.
  34. Int J Neurosci. 2011 Jun;121(6):329-36.
  35. Nat Med. 2003 Mar;9(3):294-9.
  36. J Am Soc Nephrol. 2011 May;22(5):914-26.
  37. Pharmacol Res. 2010 Jun;61(6):482-8.
  38. Diabetes Care. 2006 Sep;29(9):2064-71.
  39. Circ Heart Fail. 2010 Mar;3(2):294-305.
  40. Acta Diabetol. 2001;38(3):135-8.
  41. J Pak Med Assoc.2012 Oct;62(10):1033-8.
  42. Acta Diabetol. 2012 Dec;49 Suppl 1:S141-51.
  43. Genes Nutr. 2012 Jul;7(3):459-69.
  44. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7.
  45. Biochem Biophys Acta. 2001 Feb.14;1535(2):110-9.
  46. J Lipid Res. 2006 May; 47(5): 964-74.
  47. J Am Soc Nephrol. 2005 Jan;16(1):144-50.
  48. Life Sci. 1988;43(21):1725-31.
  49. Amino Acids. 2012 Apr;42(4):1163-70. 
  50. FASEB J. 1999 Feb;13(2):411-8.
  51. Antioxid Redox Signal. 2000 Fall;2(3):473-83.
  52. FASEB J. 2001 Mar;15(3):700-6.
  53. Arch Biochem Biophys. 2004 Mar 1;423(1):126-35.
  54. Redox Rep. 2005;10(1):52-60.
  55. Altern Med Rev. 2007 Dec;12(4):343-51.
  56. Aging Cell. 2013 Dec;12(6):1021-31.
  57. J Enzyme Inhib Med Chem. 2014 Apr;29(2):297-302.
  58. Amino Acids. 2015 Apr;47(4):735-44.
  59. Mol Vis. 2012; 18: 2673–2686.
  60. Neurosci Lett. 2015 Mar 17;590:52-7.
  61. Adv Exp Med Biol. 2015;803:397-405.
  62. Adv Exp Med Biol. 2015;803:409-13.
  63. Prog Retin Eye Res. 2014 Jul;41:44-63.
  64. Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H232-9.
  65. J Transl Med. 2015 Jul 25;13:243.

If you have any questions, please contact us at or 1-888-771-3905.
Related Products and Information


Retail Price: $52.00
Your Price: $39.00

The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Extension Institute assumes no liability for inaccuracies or misstatements about products.
Life Extension Vitamins is Upfront