Butterbur's principal active constituent, petasin, reduces smooth muscle spasms and helps relax the constriction of cerebral blood vessels. Butterbur's ability to relax constricted arteries and smooth muscle may help control head cavity discomfort. Source: Life Extension Foundation Ingredients: See below. Sale Price: $21.99 + Free Shipping Take advantage of FREE air shipping in the USA! Read More . . . Standardized Butterbur-Ginger-Riboflavin Formula In Germany, doctors are recommending a natural extract from the herb butterbur to those who suffer from regular episodes of head cavity discomfort. In clinical trials in both Germany and the United States, butterbur reduced the incidence of head cavity discomforts by up to 61%.1,2 Butterbur's principal active constituent, petasin, reduces smooth muscle spasms and helps relax the constriction of cerebral blood vessels. Butterbur's ability to relax constricted arteries and smooth muscle may help control head cavity discomfort. Life Extension's new Migra-Eeze contains butterbur root extract standardized to provide 22.5 mg of petasins with each daily dose of two softgels. Riboflavin (vitamin B2) and ginger are included based on the ability of these nutrients to exert functional changes that may also guard against head cavity discomforts. 1. Lipton RB, Gobel H, Einhaupl KM, Wilks K, Mauskop A. Neurology. 2004 Dec 28;63(12):2240-4. 2. Grossmann M, Schmidramsl H. Int J Clin Pharmacol Ther. 2000 Sep;38(9):430-5. Supplement Facts Serving Size: 2 softgels Servings Per Container: 30 Amount Per Serving Riboflavin (vitamin B2) (as riboflavin and riboflavin 5' phosphate) - 400mg Butterbur (Petasites hybridus) CO2 Extract (root) [std. to 15% petasins (22.5 mg)] - 150mg Ginger (Zinigiber officinale) Extract (root) [standardized to 5% gingerols (12.5 mg)] - 250mg Other ingredients: beeswax, lecithin, sunflower oil, gelatin, glycerin, purified water, and carob extract. Contains soybeans. This product contains NO milk, egg, fish, peanuts, crustacean shellfish, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives. Migra-Eeze� uses a patented butterbur extract carefully extracted using state-of-the-art technology to obtain key active ingredients while containing no detectable toxic pyrrolizidine alkaloids (PA). Dosage and Use Take two softgels daily in divided doses with or without food, or as recommended by a healthcare practitioner. Supplementation with Migra-Eeze� should be carried out for four to six months. Discontinue Migra-Eeze� after the initial cycle of four to six months, after which it will maintain its benefits. Resume supplementation for another four to six month cycle when symptoms begin to increase. If you have any questions, please contact us at info@lifeextensionvitamins.com, 1-510-527-3005 or 1-888-771-3905. Migra-EezeRetail Price: $29.50Sale Price: $21.99 60: softgels FREE AIR MAIL SHIPPING IN THE U.S.! The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Copyright 1997-2008 Life Extension Vitamin Supplies and Life Extension Institute, Inc. All rights reserved.