NATURAL ESTROGEN WITH POMEGRANATE EXTRACT - Phytoestrogens, Black Cohosh, Licorice Extract and More

Natural Estrogen with Pomegranate Extract is one answer to the concerns of maintaining healthy hormone function.

Source: Life Extension Foundation

Ingredients: See below.

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In an attempt to provide aging women with the multiple health effects of the bodies estrogen without side effects, scientists have discovered plant extracts with estrogenic activity (phytoestrogens).

Natural Estrogen with Pomegranate Extract is one answer to the concerns of maintaining healthy hormone function. A review of the published literature reveals some interesting findings about how plant-derived estrogens can provide safe and effective support for such menopausal symptoms as hot flashes.

Derived from organically-grown fruit, the pomegranate extract in this formula has the same ratio of polyphenols found in the whole fruit and all the benefits one would get from the juice without the sugar, calories, and additives. Punicalagins, the main polyphenol responsible for pomegranates health properties, has been shown to be a powerful antioxidant. In fact, the health effects from the juice and the seeds work synergistically providing an array of health benefits.

Scientists have identified specific extracts from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, etc.) that modulate hormones in a way to help maintain healthy cell division. For instance, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone. Found abundantly in broccoli, indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals. Human studies support the beneficial role of I3C in positively altering estrogen metabolism. Di-indoyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone. The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action.

HMRlignan is a powerful antioxidant and free radical scavenger. A naturally occurring plant lignan, HMRlignan's major component, 7-hydroxymatairesinol, is a precursor to enterolactone, a human lignan found throughout the body that acts as to protect the body from excess estrogen and its unwanted effects. Enterolactone may also limit excess cell growth in specific tissues and has also been linked to beneficial effects in menopausal women. Thus, the addition of the phyto-nutrient HMRlignan may prove beneficial to human health.

Also included in the formula is a soy extract Soyselect that significantly enhances the bioavailability of isoflavones because of its double standardized of isoflavone glycosides genistin and daidzin.

This formulation of Natural Estrogen with Pomegranate Extract contains broccoli extract and HMRlignan in addition to phytoestrogens and other plant extracts, all of which have proven to provide optimal female hormonal support.

Soy Isoflavones found to Help Relieve Menopausal Hot Flash Symptoms

A Swedish study, published in The Journal of the North American Menopause Society (14,3:468-473, May/June 2007) found that soy isoflavones significantly reduced menopausal hot flashes and night sweats. Researchers stated that the onset of these climacteric symptoms is the primary reason that perimenopausal women seek hormone therapy. In this double-blind prospective study 60 healthy postmenopausal women were randomly assigned to receive either 60 mg per day of soy isoflavones or placebo daily for 3 months. Before and after treatment, climacteric symptoms were recorded; serum was collected to measure lipoprotein lipid levels, estradiol and follicle-stimulating hormone; and biopsy specimens of endometrial and breast tissues were analyzed to investigate the expression level of steroid receptors and proliferation. Endometrial thickness was measured by ultrasound.

At the end of the trial hot flashes and night sweats were found to be reduced by 57% and 43%, respectively. Soy Isoflavone supplementation did not change levels of circulating estradiol or follicle-stimulating hormone, and breast biopsy specimens showed isoflavones did not affect expression levels of steroid receptors, estrogen receptors, progesterone receptors or the proliferation marker Ki67. No effects on body weight or lipoprotein lipids were found.

Researchers concluded that soy isoflavones supplementation could be beneficial in relieving acute symptoms of menopause.

Soy isoflavones are a class of phytoestrogens, plant compounds similar to estrogen, which are capable of binding and modulating cellular estrogen receptor cites. Soy isoflavones may exert a hormone normalizing effect in pre and postmenopausal women. Its action is determined by a woman’s endogenous estrogen levels. In the presence of excessive estrogen (e.g. PMS), isoflavones exercise an antiestrogenic effect by competing with estrogen for receptor cites. Conversely, as estrogen levels decline in menopause, isoflavones provide a mild estrogenic activity. The hormone modulating effects of soy isoflavones may be beneficial in menopause, endometriosis, cervical dysplasia, menstrual irregularities, and breast cancer prevention.

Soy isoflavones may inhibit or even reverse osteoporotic changes in menopausal women. Isoflavones are thought to help preserve bone density by a direct estrogenic action on osteoblastic cells, but may also aid by reducing osteoclastic activity. A number of studies, clinical and epidemiological, indicate that soy isoflavones may reduce risk of a number of types of cancer including hormone dependant cancers (breast and prostate) as well as certain other cancers including colon, lung and leukemia. Several mechanisms have been suggested including inhibition of tumor promoting enzymes and inhibition of tumor angiogenesis. The substitution of soy for animal protein has long been accepted as a dietary strategy for hypercholesterolemia and heart disease. More recently the soy isoflavone genistein has been found to play an important role in inhibiting platelet activation, thrombin formation and smooth muscle cell proliferation, which lead to the formation of atherosclerotic plaque.

Whole soy foods such as tofu and soymilk contain approximately 35 to 40 mg of soy isoflavones per cup serving. Dietary supplement provides a significant soy component to the diet.

Supplement Facts

Serving Size: 2 caplets

Servings Per Container: 30

Amount Per Serving

• SoySelect soybean (Glycine max) 70:1 Extract [standardized to 13% isoflavones (52 mg), 18% Group-B Saponins (72 mg)] - 400 mg
• Broccoli (Brassica oleracea l.) Super Concentrate Extract (plant) [standardized to 4% glucosinolates (12 mg)] - 300 mg
• PomElla Pomegranate (Punica granatum) Extract (fruit) [standardized to 30% Punicalagins (60 mg)] - 200 mg
• Black cohosh extract (Cimicifuga racemosa) (root and rhizome) [standardized to 2.5% triterpene glycosides (1 mg)] - 40 mg
• HMRlignan Norway spruce (Picea abies) lignan extract (knot wood) [standardized to 90% Hydroxymatairesinol potassium acetate complex (27 mg)] - 30 mg
• Dong quai extract (Angelica sinensis) (root) [std. to 1% ligustilide (.25 mg)] - 25 mg
• Licorice extract (Glycyrrhiza glabra) (root) - 25 mg
• Vitex extract (Vitex agnus-castus) (fruit) [std. to 5% vitexicarpin (1 mg)] - 20 mg

Other ingredients: dicalcium phosphate, microcrystalline cellulose, stearic acid, croscarmellose sodium, silicon dioxide, magnesium stearate, pharmaceutical glaze.

Contains soybeans. Contains corn. This product contains NO milk, egg, fish, peanuts, crustacean shellfish, tree nuts, wheat, yeast, gluten, or rice.

Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

SoySelect is a registered trademark of Indena S.p.A.

HMRlignan is a trademark used under sublicense from Linnea S.A.

PomElla is a registered trademark of Geni Herbs.

Dosage and Use

Take two caplets in the morning with or without food, or as recommended by your healthcare practitioner.

NATURAL ESTROGEN should be taken cyclically: three weeks on and one week off, beginning on the 5th day of the menstrual cycle for premenopausal women, and every day for postmenopausal women.

Those taking any estrogenic product should include as part of their diet cruciferous vegetables such as broccoli, Brussel sprouts, cabbage and/or cauliflower.

Women should also use a natural progesterone cream when taking this product.

Caution: Do not take in case of pregnancy, lactation, or estrogendependent tumors.

If you have any questions, please contact us at info@lifeextensionvitamins.com or 1-888-771-3905.

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