Life Extension Optimized Folate (L-Methylfolate), 1000mcg 100 vegetarian capsules, Item# 01439
Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.
Those who take ordinary folic acid supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF).1 Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).
A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise blood serum folate levels2 compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency3 since it requires no conversion to become metabolically active.
A study of 10 patients with endothelial dysfunction showed complete reversal of endothelial impairment after 5-MTHF supplementation compared with healthy control patients.4
People with elevated homocysteine levels have a greater risk of cognitive decline.5 Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier to enhance brain synthesis of acetylcholine—the neurotransmitter associated with memory, which is especially important for people with cognitive difficulties. Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12),6 vitamin B6, and riboflavin.7Key advantages of 5-MTHF
Supplement FactsServing Size:
- Seven times more bioavailable than folic acid
- Supports cardiovascular health and nervous system function
1 vegetarian capsuleServings Per Container:
100Amount Per Serving
- Folate (as 5-Methyltetrahydrofolic acid (5-MTHF), and calculated based upon the biologically Active 6S isomer) - 1000mcg
microcrystalline cellulose, vegetarian capsule, magnesium stearate, silicon dioxide.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.Dosage and Use:
Take one capsule daily with meals, or as recommended by a healthcare practitioner.References
1. BMJ. 2004;328(7455):1535-6.
2. Am J Clin Nutr. 2006 Jul;84(1):156-61
3. Br J Pharmacol. 2004 Mar;141(5):825-30.
4. Circulation. Jan 27 1998;97(3):237-41.
5. N Engl J Med. 2002 Feb 14;346(7):476-83.
6. Nephrol Dial Transplant. May 2002;17(5):916-22.
7. Clin Chem. 2000 Aug;46(8 Pt 1):1065-71.
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