~ PS (Phosphatidylserine), Vitamin E, and Brain Aging

Many people experience a progressive decline in overall cognitive function as they age. Often this begins with a loss in their ability to store and retrieve from short-term memory and to learn new information that progressively worsens over the years.

Phosphatidylserine plays an important role in maintaining the integrity of brain cell membranes. The breakdown of brain cell membranes prevents glucose and other nutrients from entering the cell. By protecting the integrity of brain cell membranes, phosphatidylserine facilitates the efficient transport of energy-producing nutrients into cells, enhancing brain cell energy metabolism.

Abnormalities in the composition of phosphatidylserine have been found in patients with Alzheimer's disease (Corrigan et al. 1998).

The recommended dose of phosphatidylserine (PS) is 100 to 300 mg a day.

Free radicals are atoms or groups of atoms that can cause damage to cells by a process known as oxidation, which impairs the immune system and leads to infections and degenerative diseases. Free radicals occur as a result of air pollutants, smoke, radiation, environmental toxins, and processed foods, and are also released in the human body through sun exposure and stress. Antioxidants neutralize free radicals and help prevent such free-radical damage as normal brain aging. Their destructive activity has been implicated in many disease processes, including stroke and heart disease.

A study by Perrig et al. (1997) compared groups of older people over time and at a given moment with regard to antioxidant intake and memory performance. The study found that free recall, recognition, and vocabulary were significantly related to vitamin C and beta-carotene levels. The levels of these antioxidants were found to be significant predictors of cognitive function even after adjusting for possible confounding variables such as differences in education, age, and gender.

Life Extension Mix is a multinutrient formula that contains the ideal potencies of antioxidants, vitamins C and E, and beta carotene. It provides an easy and cost-effective way to supplement the optimal combination of vitamins, minerals, amino acids, and antioxidants.

Gamma E Tocopherol/Tocotrienol

The term "vitamin E" refers to a family of eight related, lipid-soluble, antioxidant compounds widely distributed in plants. The tocopherol and tocotrienol subfamilies are each composed of alpha, beta, gamma and delta vitamers having unique biological effects. Different ratios of these compounds are found in anatomically different parts of a plant. For example, the green parts of a plant contain mostly alpha tocopherol and the seed germ and bran contain mostly tocotrienols.

One or more members of the vitamin E family may:

  • Maintain cell membrane integrity and reduce cellular aging
  • Inhibit the potentially damaging peroxynitrite radical
  • Inhibit melanoma cell growth in mice
  • Prevent abnormal blood clotting
  • Synergize with vitamin A to protect the lungs against pollutants
  • Protect nervous system and retina
  • Lower the risk of ischemic and coronary heart disease
  • Lower the risk of certain kinds of cancer
  • Protect immune function
  • Reduce the risk of Alzheimer's disease


Phosphatidylserine Capsules

In 1988, the Foundation published an article about studies in Europe showing phosphatidylserine could slow and reverse the rate of brain cell aging in laboratory animals. Phosphatidylserine restored mental function in older animals to levels exceeding those found in some younger animals. Although studies in humans with Alzheimer's disease were less dramatic, they still produced significant improvements in cognitive function. In patients with mild dementia, significant cognitive and behavioral enhancing effects were observed. In one study with mildly demented elderly patients, the improvement in neural function continued 30 days after discontinuing phosphatidylserine (PS) therapy. This suggests that relatively low doses or cyclical dosing of PS therapy over an extended period of time in healthy people may produce sustained antiaging results.
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