SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body that is excellent for muscle pain, fibromyalgia, joint pain, rheumatoid arthritis, depression and liver disease. Source: Life Extension Foundation Ingredients: S-adenosyl-methionine - 200mg Sale Price: $18.95 Quantity Price: 4 packs for $69.99 Take advantage of FREE air shipping in the USA! Read More . . . Excellent for muscle pain, fibromyalgia, joint pain, rheumatoid arthritis, depression and liver disease. SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways: Methylation (contributing methyl groups to activate certain molecules). The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.) Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals). In young, healthy people SAMe is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. However, in sickness and in age, system levels may become depleted. Supplementation of the co-factors folate, TMG, vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe may help to synthesize phosphatidylcholine, which keeps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine. An agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe in year 2002. Their findings show the efficacy of SAMe in helping maintain stable mood and joint function, without any side effects. Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older. SAMe (S-adenosyl-methionine) has multi-modal mechanisms of action that are used throughout the body, and especially the liver. In order to perform its detoxification role, the liver performs thousands of complex enzymatic reactions every second. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant, glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health. Supplement Facts Serving Size: 2 tablets Servings Per Container: 10 Amount Per Serving S-adenosyl-methionine - 400mg Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica, titanium dioxide, and yellow ochre. Dosage and Use One to four tablets daily are suggested. Taking this product with food may avoid gastrointestinal disturbance. Refrigeration is recommended. Take folic acid, vitamins B12, and B6 when using SAMe. Caution: Do not use SAMe with antidepressant medications except under a doctor's care. At levels above 400 mg daily, SAMe may cause dry mouth, restlessness and gastrointestinal problems. Cutting back on dosage and then increasing it slowly should alleviate these symptoms. When using nutritional supplements, please inform your physician if you are undergoing treatment for a medical condition. How to Order To order online, click on the "Order" box below. To see a list of all supplements, please check our Index or use our Search feature. If you have any questions, please contact us at info@lifeextensionvitamins.com, 1-510-527-3005 or 1-888-771-3905. same200bp$18.95 20: tabs/200mg.ea SAMe 200mg Quantity Price for 4 packs same200blisquant$69.99 FREE AIR MAIL SHIPPING IN THE UNITED STATES! The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Copyright 1997-2009 Life Extension Vitamin Supplies and Life Extension Institute, Inc. All rights reserved.