Source: Life Extension Foundation Ingredients: See below. Sale Price: $28.65 Take advantage of FREE air shipping in the USA! Read More . . . Tocotrienols have shown superior action in maintaining arterial health. This wonder nutrient is so effective because of its structure of double bonds in the isoprenoid side chain, making it a great scavenger of free radicals. Sesame lignans have been added to help block or inhibit the enzyme that breaks down tocotrienols allowing tissue levels of tocotrienols to build up in the body. This translates into much greater antioxidant protection, decreasing destructive free radicals. A study of Swedish women showed supplementing with sesame oil increased gamma-tocopherol levels 41.7% without any other sources of tocopherols.1 Sesame lignans have been shown to have the ability to lower a measure of oxidative cell membrane/DNA damage by 82%.2 The Isoprostane marker measures the amount of cell membrane (also called lipid peroxidation) damage caused by free radicals.3,4 Our own in-house study showed a reduction in serum Isoprostane levels after two weeks of supplementation of tocopherols with sesame. The in-house study also showed a substantial decrease of dityrosine (marker which measures serum levels of deep tissue protein oxidation caused by peroxynitrite radical reacting with tyrosine) by 22%. [Lemcke-Norojarvi M. Corn and sesame oils increase serum gamma-tocopherol concentrations in healthy Swedish women. J. Nutr. 2001;131:1195-1201] Kang MH, Naito M. Mode of action of sesame lignans in protecting LDL against oxidative damage in vitro. Life Sci. 2000;66(2):161-7. Cracowski JL, Durand T, Bessard G. Isoprostanes as a biomarked of lipid peroxidation in humans: physiology and clinical implications. Trends Pharmacol Sci. 2002 Aug;23(8):360-6. Roberts LJ, Morrow JD. Measurement of F(2) isoprostanes as an index of oxidative stress in vivo. Free Radic Biol. Med. 2000 Feb 15;28(4):505-13. Supplement Facts Serving Size: 1 softgel Servings Per Container: 60 Amount Per Serving Vitamin E (as D-alpha tocopherol) - 31.3 IU TocominŽ Full-Spectrum Natural Tocotrienol Complex - 75mg Typical distribution: Gamma tocotrienol - 41.7-50mg Alpha tocotrienol - 20.9-29.2mg Delta tocotrienol - 10.4-14.6mg Beta tocotrienol - 2.1mg Sesame seed (Sesamum indicum) lignan extract [standardized to 60% sesamin (12 mg)] - 20mg Other ingredients: gelatin, glycerin, water, and rosemary extract. To keep our products pure and natural no color has been added to these softgelatin capsules. The natural separation of active ingredients may occur. This product contains TocominŽ Full-Spectrum Palm Tocotrienol Complex. TocominŽ is the registered trademark of Carotech, Inc. and protected by US Patent No.: 5,157,132. Dosage and Use: Take one softgel per day. For optimal absorption, take with food. Caution: Because Vitamin E inhibits blood clotting, use with caution if you are taking anticoagulant drugs or have a bleeding disorder. This product should not be used by individuals who have an allergy to sesame. How to Order To order online, click on the "Order" box below. To see a list of all supplements, please check our Index or use our Search feature. If you have any questions, please contact us at info@lifeextensionvitamins.com, 1-510-527-3005 or 1-888-771-3905. sesametocsRetail Price: $38.00Sale Price: $28.65 60: softgels FREE AIR MAIL SHIPPING IN THE UNITED STATES! The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Copyright 1997-2009 Life Extension Vitamin Supplies and Life Extension Institute, Inc. All rights reserved.