~ Vitamin C May Have Beneficial Effects on Nitric Oxide Bioavailability Induced by L-Arginine

NewsRx.com, 11-04-05

Researchers have investigated the effects of vitamin C on intracoronary L-arginine-dependent coronary vasodilatation in patients with stable angina.

Scientists in Greece conducted a study "to assess the effects of intravenous vitamin C administration on the vasomotor responses to intracoronary L-arginine infusion in epicardial coronary arteries."

D. Tousoulis and colleagues of the University of Athens explained, "28 patients with coronary artery disease and stable angina were enrolled in the study. Eight patients received intracoronary infusions of 150 mmol/min L-arginine before and after intravenous infusion of vitamin C, 10 patients received intracoronary infusions of 150 mcmol/min L-arginine before and after intravenous infusion of normal saline, and 10 patients received intracoronary normal saline before and after intravenous infusion of vitamin C. The diameter of proximal and distal coronary artery segments was measured by quantitative angiography."

"Infusion of L-arginine caused significant dilatation of both proximal (4.87 (0.96)%, p<0.01 vs. normal saline) and distal (6.33 (1.38)%, p<0.01 vs. normal saline) coronary segments," the researchers reported. "Co-infusion of vitamin C and L-arginine dilated proximal coronary segments by 8.68 (1.40)% (p<0.01 vs. normal saline, p<0.01 vs. L-arginine) and distal segments by 13.07 (2.15)% (p<0.01 vs. normal saline, p<0.01 vs. L-arginine)."

"Intravenous infusion of vitamin C caused a borderline increase in proximal and distal coronary segment diameters(1.93 (0.76)% and 2.09 (1.28)%, respectively, not significant)," the authors noted.

They concluded, "L-arginine dependent coronary segment vasodilatation was augmented by the antioxidant vitamin C in patients with coronary artery disease. Thus, vitamin C may have beneficial effects on nitric oxide bioavailability induced by L-arginine."

Tousoulis and colleagues published their study in Heart (Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina. Heart, 2005;91(10):1319-1323).

For additional information, contact D. Tousoulis, University of Athens School of Medicine, S Karagiorga 69, Athens 16675, Greece. drtousoulis@hotmail.com

The publisher's contact information for the journal Heart is: BMJ Publishing Group, British Medical Association House, Tavistock Square, London WC1H 9JR, England.

This article was prepared by Biotech Week editors from staff and other reports. Copyright 2005, Biotech Week via NewsRx.com.

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